Water extract of Lentinus squarrosulus mycelia was analysed for nutritional content, antioxidant capacity, and antiulcer ability. The extract contains high protein (57.6?g/100?g) and low total fat (0.5?g/100?g) and is rich in magnesium (0.4?g/100?g), potassium (3.8?g/100?g), vitamins B1 (1.42?mg/100?g), and B3 (194.29?mg/100?g) with total phenolic content of 39.16?mg/100?g. The cupric reducing antioxidant capacity and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity of the extract were A450 of 0.20 �± 0.03 at 0.5?mg/ml and IC50 of 14.29?mg/ml, respectively. Oral feeding of L. squarrosulus extract (250?mg/kg) offered significant gastric mucosal protection of Sprague-Dawley rats compared to cimetidine (50?mg/kg). The ulcer healing rate of ulcerated rats after 24, 48, and 72 hours of treatment was 82%, 90%, and 100%, respectively. The IL-1�Ÿ level in the serum and the NF-?B level in the tissues indicate that the healing potential was associated with attenuation of proinflammatory cytokines.
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